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Requirements for the assessment of level of evidence for an additional benefit [4]
| Conclusion | Requirement | ||
|---|---|---|---|
| Number of studies | Certainty of results | Effect | |
| Proof | ≥2 | Mostly high | In the same direction |
| Indication | ≥2 | Mostly moderate | In the same direction |
| 1 | High | Statistically significant | |
| Hint | ≥2 | Mostly low | In the same direction |
| 1 | Moderate | Statistically significant | |
