Fig. 9.

β₈-Integrin regulates migration on a RGD-containing matrix. A–F: scratch migration assays for fibroblasts expressing β₈-integrin (CHO-B2/v7-β8; A, C, and E) and devoid of β₈-integrin (CHO-B2/v7; B, D, and F) plated on latency-associated peptide-β₁ (LAP; A and B), VN (C and D), or PLL (E and F), all at 5 μg/ml, for 14 h. Lines represent the width of the scratch at time 0. G: quantification of the scratch migration data. Results are representative of 3 scratches/well. *P < 0.05 compared with CHO-B2/v7 cells. H and I: morphology of CHO-B2/v7-β8 cells on LAP (5 μg/ml, 2 h; H) or glass coverslips (I). Actin was stained in red with phalloidin. Arrows mark lamellipodia.