Fig. 5.

Ron mediated changes in cell-matrix molecules following the induction of colitis. Western analyses of colon tissue from TK+/+ and TK−/− mice before (Ctrl) and after DSS-induced chronic colitis showing changes in the expression of various cell-matrix interacting molecules (A). Each lane represents an independent colon sample. Densitometry analyses normalized to β-actin are shown (B). IHC analyses on colons for laminin and plectin (C) showing diminished expression of these molecules in colons of TK−/− mice following the induction of chronic colitis. Scale bar = 50 μm. Images are representative of n = 5–6 mice per group with histograms representing the mean ± SE of n = 5–6 per group. *P < 0.05.