Table 1.
Results of ANOVA statistical tests for studies 1, 2 and 3 showing F-statistics and significant differences (P < 0.05) for differences across conditions
| Ghrelin Nadir |
D-AUC3h |
D-AUCtotal |
||||
|---|---|---|---|---|---|---|
| Study 1: Infusions of glucose, 3-O-MG, and lactulose | ||||||
| Dose effects | ||||||
| Glucose | F(3,27) = 12 | P < 0.001 | F(3,27) = 18 | P < 0.001 | F(3,27) = 5.8 | P = 0.003 |
| 3-O-MG | F(3,25) = 3.5 | P = 0.03 | F(3,25) = 5.8 | P = 0.004 | NS | |
| Lactulose | F(3,30) = 3.4 | P = 0.03 | F(3,30) = 3.4 | P < 0.03 | NS | |
| Substance effects | ||||||
| Isotonic | NS | NS | NS | |||
| 2.5-fold hypertonic | F(2,18) = 4.5 | P = 0.02 | NS | NS | ||
| 5-fold hypertonic | F(3,23) = 6.3 | P = 0.003 | F(3,23) = 20 | P < 0.001 | F(3,23) = 3.5 | P = 0.03 |
| Study 2: Infusions of isotonic saline, 5-fold hypertonic saline, and 5-fold hypertonic saline + lidocaine | ||||||
| Between-condition effect | F(2,20) = 7.6 | P = 0.003 | F(2,20) = 4.3 | P = 0.03 | NS | |
| Study 3: Infusions of Intralipid, isocaloric glucose, and iso-osmotic Intralipid + lactulose | ||||||
| Between-condition effect | F(2,13) = 10 | P = 0.002 | F(2,13) = 34 | P < 0.001 | F(2,13) = 6.6 | P = 0.01 |
Data are shown for 3 parameters of plasma ghrelin responses to infusions: ghrelin nadir, i.e., ghrelin levels at maximum suppression and D-AUC3 h and D-AUCtot, i.e., the decremental area under the ghrelin curve for the 3-h and 5-h postinfusion time intervals, respectively. Post hoc test results with Bonferroni correction are described in the main text. Results for a fourth parameter, time to ghrelin nadir (TGN) were all nonsignificant and were omitted from the table. 3-O-MG, 3-O-methylglucose. NS, nonsignificance (P > 0.05).