Table 4.
Multivariable Cox regression model for event-free survival including molecular subgrouping, age at diagnosis, M stage, residual disease, histopathological subtype and MYC status
| Variable | Available cases | HR | 95 % CI | p* |
|---|---|---|---|---|
| Age at diagnosis | N/S*** | |||
| <4 vs. >4 | 33 vs. 133 | – | – | |
| M_Stage | 0.045 | |||
| M1–M4 vs. M0 | 66 vs. 100 | 2.064 | 0.998–4.269 | |
| Residual tumor | N/S*** | |||
| >1.5 cm2 vs. <1.5 cm2 | 21 vs. 145 | – | – | |
| WHO classification | N/S*** | |||
| Desmoplastic/nodular vs. classic | 33 vs. 119 | – | – | |
| MBEN vs. classic | 5 vs. 119 | – | – | |
| Anaplastic vs. classic | 8 vs. 119 | – | – | |
| Large cell vs. classic | 1 vs. 119 | – | – | |
| MYC_status | N/S*** | |||
| Amplified vs. balanced | 7 vs. 159 | – | – | |
| 450k subgrouping | 0.032 | |||
| Group_3 vs. Group_4 | 45 vs. 70 | 2.141 | 1.042–4.400 | |
| SHH vs. Group_4 | 38 vs. 70 | 1.329 | 0.497–3.556 | |
| SHH vs. Group_3 | 38 vs. 45 | 0.621 | 0.234–1.644 | |
| WNT vs. Group_4 | 13 vs. 70 | NE | – |
Estimated hazard ratio (HR) with 95 % confidence interval (CI) and p value of the likelihood ratio test for omnibus test
NE not estimable (because there are no events in this group)
* p value of the likelihood ratio test for omnibus test. For pairwise comparisons, confidence intervals instead of p values are given (p value of Wald test ≤0.05 if and only if confidence interval does not contain 1)
*** N/S not selected in the final multivariable model (inclusion: p value Score test ≤0.05, exclusion: p value likelihood ratio test >0.1)