Table 1.

The rate of oxidative phosphorylation in mouse heart mitochondria following 25 min ischemia and 30 min reperfusion using glutamate + malate as complex I substrates

	State 3	State 4	RCR	ADP/O
Time control (n = 6)	267 ± 10	25 ± 1	11.3 ± 0.6	3.01 ± 0.07
IR (n = 6)	144 ± 10*	37 ± 2*	3.9 ± 0.3*	2.80 ± 0.07
Acidification + IR (n = 9)	156 ± 9*	30 ± 1*†	5.4 ± 0.5*†	2.96 ± 0.07

Values are means ± SE. RCR, respiratory control ratio; ADP/O, adenosine diphosphate-to-oxygen phosphorylation ratio.

^*P < 0.05 vs. time control;

^†P < 0.05 vs. ischemia-reperfusion (IR).