Table 3.
Ten most significant biological functions and disease signatures predicted to be regulated by O3-responsive miRNAs
| Biological Function or Disease Signature* | P Value | Number of Inflammation-Associated Transcripts/Total Number of Transcripts | Inflammation-Associated Transcripts |
|---|---|---|---|
| Cell cycle | 1.29E-26 | 33/81 | BCL2, BCL2L11, CCND3, CD44, CDK6, CDKN1A, CDKN1B, ESR1, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSPA1A/HSPA1B, IKZF1, ITGA5, JUN, MDM2, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, RECK, SIRT1, SOD2, VEGFA, WNT3A, WT1 |
| Cell death and survival | 3.99E-26 | 43/135 | ARHGDIA, BCL2, BCL2L11, BDNF, CARD8, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSP90B1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP1, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, RECK, SIRT1, SOD2, TIA1, TIMP3, VEGFA, WNT3A, WT1 |
| Cancer | 6.58E-26 | 46/167 | ARHGDIA, BCL2, BCL2L11, BDNF, CACNA2D1, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, F11R, FGF2, FGFR1, FOS, FOXO3, H3F3A/H3F3B, HBEGF, HIF1A, HMOX1, HSP90B1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP1, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, RECK, SIRT1, SLC7A1, SOD2, TIMP3, TJP1, VEGFA, WNT3A, WT1 |
| Cellular development | 4.16E-25 | 43/121 | ARHGDIA, BCL2, BCL2L11, BDNF, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, F11R, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSP90B1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP1, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, RECK, SIRT1, SOD2, TIMP3, TJP1, VEGFA, WNT3A, WT1 |
| Cellular growth and proliferation | 4.16E-25 | 43/127 | ARHGDIA, BCL2, BCL2L11, BDNF, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, F11R, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSP90B1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP1, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, RECK, SIRT1, SOD2, TIMP3, TJP1, VEGFA, WNT3A, WT1 |
| Tumor morphology | 4.16E-25 | 36/72 | BCL2, BCL2L11, BDNF, CARD8, CCND3, CD44, CDK6, CDKN1A, CDKN1B, ESR1, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP1, MMP9, MTOR, PTEN, PTGS2, RB1, RECK, SIRT1, TIMP3, VEGFA, WNT3A, WT1 |
| Tissue morphology | 3.59E-22 | 42/98 | ARHGDIA, BCL2, BCL2L11, BDNF, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, F11R, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSP90B1, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, RECK, SIRT1, SLC7A1, SOD2, TIA1, TIMP3, VEGFA, WNT3A, WT1 |
| Organismal survival | 3.97E-22 | 42/109 | ARHGDIA, BCL2, BCL2L11, BDNF, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSP90B1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, RECK, SIRT1, SLC7A1, SOD2, TIA1, TIMP3, VEGFA, WNT3A, WT1 |
| Hematological system development and function | 1.21E-19 | 42/93 | ARHGDIA, BCL2, BCL2L11, BDNF, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, F11R, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSP90B1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP9, MTOR, PPP3CA, PTEN, PTGS2, PURA, RB1, SIRT1, SLC7A1, SOD2, TIA1, TIMP3, VEGFA, WNT3A, WT1 |
| Cell morphology | 1.55E-19 | 40/102 | ARHGDIA, BCL2, BCL2L11, BDNF, CCND3, CD44, CDK6, CDKN1A, CDKN1B, DDR1, ESR1, F11R, FGF2, FGFR1, FOS, FOXO3, HBEGF, HIF1A, HMOX1, HSPA1A/HSPA1B, ICAM1, IKZF1, ITGA5, JUN, MCL1, MDM2, MMP9, MTOR, PTEN, PURA, RB1, RECK, SIRT1, SLC7A1, SOD2, TIMP3, TJP1, VEGFA, WNT3A, WT1 |
*
Based on 268 mRNA predicted targets from 7 O3-responsive miRNAs.