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. 2014 Jun 17;4:155. doi: 10.3389/fonc.2014.00155

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Copyright © 2014 Thorne.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selective replication of an oncolytic virus within an infected tumor cell might be engineered in multiple ways to optimize the kinetics, type, and level of resultant immune response. The approaches covered in this perspective are summarized here, along with their range of activity (local acting within the tumor, or systemic activity) and whether immune activation or blocking of immune suppression are involved. Ideal combination approaches would be predicted to involve components of different quadrants in the figure.