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. 2014 Jun 17;5:225. doi: 10.3389/fphys.2014.00225

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Copyright © 2014 Biechler, Junor, Evans, Eberth, Price, Potts, Yost and Goodwin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow affects fibrous extracellular matrix protein localization in outflow tract. Outflow tract (OFT) explant samples were stained with Dapi (blue) or for several hallmark extracellular matrix (ECM) proteins (green): (A) Tenascin C (B) Periostin (C) Elastin (D) Type 6 Collagen (Col6). In all no flow controls, ECM staining was throughout the tissue network, with a greater staining concentration at the scaffold interface. In each case of flow, tenascin C, periostin, and Col6 were localized toward the inlet side of the cushion (A,B,D) while elastin staining presented throughout the cushions with greater concentration on the outlet side. Scale bars are all 100 μm. The dotted lines indicate the scaffold wall.