Fig. 3.

Decrease (%) in knee swelling (A), and pain (%) in each hind paw (B) in MIA-induced OA rats after IA administration of PX/HA at different weight ratios. A, % decrease in knee swelling at 2 days after dosing versus prior to drug injection. B, % suppression of weight distribution imbalance at 2 days after dosing. Bar represents S.E. (n=8), and statistical analysis was performed using the Student’s t-test (^*p<0.05 versus vehicle-treated group; ^**p<0.05 versus greater than the sum of the values produced by each drug at the same dose).