Table 2.
Comparison between the mean pharmacokinetic parameters of PX after IM or IA injection of PX alone or after IA injection of PX/HA combination in rats
| IM PX | IA PX | IA PX/HA | |
|---|---|---|---|
| AUC(0–24h) (μg•h/ml)a | 69.5 ± 22.4 | 59.0 ± 12.1 | 62.5 ± 11.5 |
| AUC(0-∞) (μg•h/ml)a | 70.8 ±22.7 | 60.1 ± 13.1 | 64.4 ± 12.6 |
| Cmax (μg/ml)a | 5.3 ± 0.7 | 5.1 ± 0.7 | 5.1 ± 0.3 |
| Tmax (h)a | 0.80 ± 0.48 | 0.90 ± 0.52 | 1.10 ± 0.52 |
| t1/2 (h)a | 7.3 ± 1.4 | 8.1 ± 0.9 | 9.0 ± 0.8 |
| Relative BAb | - | 84.9 | 89.9 |
a
Data are expressed as mean ± S.D.
b
Calculated as percentage of the mean AUC(0–24h) of each group to that of IM PX-treated group.
Note: There were no statistically significant differences (p>0.05) between the groups in all parameters.