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. 2011 Dec 16;4(12):1591–1606. doi: 10.3390/ph4121591

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)

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Characterization of PEI/siRNA complexes. (A) SiRNA complexation efficiencies of the parent PEI F25-LMW (black circles) and the novel PEI conjugates, PEG-PEI (blue rectangles) and CRM197-PEG-PEI (red triangles). (B) Stabilities of siRNA complexes against polyanions (heparin displacement assay). After incubation in the presence of various concentrations of heparin as indicated in the figure, complexes were analysed by agarose gel electrophoresis followed by autoradiography and quantitation of the ³²P-labeled free or complexed siRNA (left panels; see right panels for original gels). (C) Hydrodynamic diameters of PEI/siRNA complexes as determined by photon correlation spectroscopy, and (D) surface charges (zeta potentials) of the complexes as determined by laser doppler anemometry.