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. 2011 Dec 16;4(12):1591–1606. doi: 10.3390/ph4121591

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)

PMC Copyright notice

CRM197-PEG-PEI-mediated anti-tumor effects of CRM197-PEG-PEI/siRNA complexes targeting pleiotrophin (PTN). (A) After establishment of s.c. U87 glioblastoma xenografts, athymic nude mice were treated by intraperitoneal injection of PTN-specific CRM197-PEG-PEI/siRNA complexes (red triangles) or PEG-PEI/siRNA complexes (blue rectangles) at the time points indicated, or were left untreated (black circles). Left panel: quantitation of tumor sizes during the treatment (12 tumors per group; p < 0.02 between CRM-PEG-PEI/siRNA and PEG-PEI/siRNA or CRM-PEG-PEI/siRNA and untreated, respectively); right panel: pictures of representative mice from each group upon termination of the experiment. (B) PTN serum levels after termination of the experiment, as determined by ELISA (serum of six mice per group).