Table 1. p.Tyr179Cys and p.Gly396Asp allele frequencies in MAP and CRC patients and in controls from different populations.

Study group	Country or population	N. subjects tested	p.Tyr179Cys allele frequency (%)	p.Gly396Asp allele frequency (%)	References
Classical or attenuated polyposis cases	Germany	544	5.5	4.5	6, 7
	Italy	110	9.2	4.1	8, 9, 10
	Sweden	15	16.8	3.2	3
	Netherlands	170	12	4.7	11
	Czech Republic	86	1.7	1.7	12, 13
	France	61	9	7.3	14, 15
	Switzerland	79	3.8	2.6	16
	Portugal	160	10.3	8.4	17, 18
	UK-Denmark-Finland	258	5.4	3.3	4, 19
	Spain	254	2.2	3.7	20, 21
	Canada (European origin)	20	9.9	5.1	22
	North America	188	10.9	5.8	23, 24
	Brazil	30	5	6.6	25
	Australia	120	7.9	4	26
	Taiwan	66	0	0	27
	South Korea	62	0	0	28
	Japan	56	0	0	29, 30
	Indians/Pakistani	6	0	0	19, 31
	Singapore	3	0	0	32
	Morocco	13	7.7	15.4	33
	Tunisia	10	0	5	34
Unselected CRC cases	UK (white)	9268	0.5	0.9	35
	Spain	1116	0.2	0.3	36
	Canada-Australia-USA	3811	0.4	1.2	37
	North America	444	0.9	0.7	24
	Morocco	49	0	0	33
	Tunisia	83	0.6	1.1	34
	Arabs	327	0	0.2	38
	Moroccan Jews	232	0.4	3.4	38
	Ashkenazi Jews	189	0	0	38
Controls	Germany	116	0.4	0.4	6
	Italy	247	0.2	0	39
	Sweden	466	0.2	0.1	40
	Czech Republic	100	0	0	12
	France	1121	0.2	0.7	41
	UK (white)	5064	0.3	0.7	35, 42
	UK	461	0.2	0.1	4, 43
	Scotland	2649	0.3	0.6	44, 45
	Finland	424	0	0	46
	Spain	1231	0.04	1.1	36, 47
	Canada-Australia-USA	2802	0.2	0.6	37
	North America	313	0.3	0.3	24
	Canada	2067	0.2	0.6	22, 48
	Caucasian/Hispanic (US)	32	0	1.6	49
	Caucasian (US)	360	0.3	0.6	49
	Australia	478	0.4	0.1	50
	Chinaa	101	0	0	51
	Arabs	304	0	0	38
	Moroccans	400	0.1	0.4	52
	Sephardi Moroccan Jews	541	0.4	1.8	53
	Jews (US)	450	0	0	49

Abbreviation: CRC, colorectal cancer.

^aThe study population was represented by patients with gastric carcinoma.