Table 2. Frequencies of the most common microsatellite alleles of the MUTYH region in p.Tyr179Cys and p.Gly396Asp cases and in controls.

	Markers (allele size range in bp)a
Study group	D1S421 (142-152)	D1S451b (240-270)		D1S2677b (159-181)		D1S3175 (153-169)	D1S2874c (226-244)		D1S2824 (234-256)
p.Tyr179Cys
Most frequent alleles in cases	148	252		167		157	228	230	240
Cases (n=60 chromosomes)
Allele frequencies	0.95	0.90		0.97		0.87	0.37	0.40	0.35
Controls (n=288 chromosomes)
Allele frequencies	0.57	0.23		0.38		0.60	0.19	0.32	0.31
P-value	<0.01	<0.001		<0.001		<0.001	NS	NS	NS
p.Gly396Asp
Most frequent alleles in cases	148	250	252	175	177	157	230		238
Cases (n=49 chromosomes)
Allele frequencies	0.88	0.35	0.41	0.41	0.39	0.90	0.59		0.29
Controls (n=288 chromosomes)
Allele frequencies	0.57	0.38	0.23	0.007	0.05	0.60	0.32		0.24
P-value	NS	NS	NS	<0.001	<0.001	<0.001	0.21		NS

Abbreviation: NS, not significant.

^aAlleles showing statistically significant association (corrected P-value <0.05) are underlined.

^bTwo common alleles with similar frequencies were observed in p.Gly396Asp chromosomes at this locus.

^cTwo common alleles with similar frequencies were observed in p.Tyr179Cys chromosomes at this locus.