Figure 3.

White matter anomalies in patients diagnosed with RIN2 and GORAB mutations. (a) Axial FLAIR images of patient 1 diagnosed with MACS syndrome at the age of 18, showing periventricular white matter disease with cystic lesions in the white matter. The U fibers are spared. (b, c) Mild white matter changes in the periventricular white matter and in the corpus callosum on axial T2 images in patients 14 and 15 at age of 10 and 16 years, diagnosed with GO syndrome, intellectual disability and spasticity.