Table 3. Association of SLC2A9 SNP with renal function in combined centers samplea.
Serum creatinine | Estimated GFR | Albumin/creatinine ratio | ||||
---|---|---|---|---|---|---|
SNPs | Effect sizea (%) | P-value | Effect size (%) | P-value | Effect size (%) | P-value |
rs16890979 | 0.53 | 0.0013 | 0.52 | 0.0015 | 0.13 | 0.066 |
rs6832439 | 0.54 | 0.0017 | 0.52 | 0.0019 | 0.16 | 0.051 |
rs6449213 | 0.27 | 0.0028 | 0.22 | 0.08 | 0.01 | 0.639 |
rs13131257 | 0.60 | 0.00007 | 0.58 | 0.0009 | 0.14 | 0.050 |
rs737267 | 0.46 | 0.004 | 0.44 | 0.0044 | 0.14 | 0.056 |
rs10805346 | 0.68 | 0.00005 | 0.69 | 0.00008 | 0.14 | 0.102 |
rs12498956 | 0.23 | 0.058 | 0.24 | 0.047 | 0.07 | 0.153 |
Effect size – proportion of residual phenotypic variance that is explained by the SNP.
Final model included covariates age, sex, age × sex, age2 and age2 × sex.