Table 1.
Lassomycin spectrum of activity.
| Strains | MIC, μg/ml | MIC, μM |
|---|---|---|
| M. tuberculosis | ||
| H37Rv | 0.78–1.56 | 0.41–0.83 |
| 186, susceptible clinical isolate | 1.56 | 0.83 |
| 83, susceptible clinical isolate | 1.56–3.1 | 0.83–1.65 |
| 84, resistant to INH, STR | 1.56–3.1 | 0.83–1.65 |
| 85, resistant to INH, RIF | 1.56–3.1 | 0.83–1.65 |
| 7, resistant to INH, RIF | 1.56 | 0.83 |
| 86, resistant to INH, RIF, STR | 1.56 | 0.83 |
| 136, resistant to INH, RIF, STR, FQ | 0.78 | 0.41 |
| 133, resistant to INH, RIF, STR, FQ | 0.78 | 0.41 |
| 189, resistant to INH, RIF, STR, FQ | 3.1 | 1.65 |
| 3, resistant to INH, RIF, EMB, FQ | 3.1 | 1.65 |
| 30, resistant to INH, RIF, EMB, PZA, FQ | 0.78 | 0.41 |
| 181, resistant to INH, RIF, EMB, PZA, FQ | 0.78 | 0.41 |
| 183, resistant to INH, RIF, STR, EMB, PZA, FQ | 3.1 | 1.65 |
| 188, resistant to INH, RIF, STR, EMB, PZA, FQ | 3.1 | 1.65 |
| mc26020 | 0.39 – 0.78 | 0.21–0.41 |
| Other Mycobacteria | ||
| M. avium subsp. Paratuberculosis | 0.125 – 0.25 | 0.07–0.13 |
| M. smegmatis | 0.78 – 2 | 0.41–1.06 |
| Other Actinobacteria | ||
| Propionibacterium acnes | 12.5 – 25 | 6.7–13 |
| Bifidobacterium longum | 25 – 50 | 13–27 |
| Other Gram-positive bacteria | ||
| Clostridium difficile | >50 | >27 |
| Clostridium perfringens | >50 | >27 |
| Lactobacillus reuteri | >50 | >27 |
| Lactobacillus casei | >50 | >27 |
| Streptococcus mutans | >50 | >27 |
| Enterococcus faecalis | >50 | >27 |
| Enterococcus faecalis VRE | >50 | >27 |
| Bacillus anthracis Sterne | >50 | >27 |
| Staphylococcus aureus | >50 | >27 |
| Gram-negative bacteria | ||
| Bacteroides fragilis | >50 | >27 |
| Escherichia coli K12 | >50 | >27 |
| Klebsiella pneumoniae | >50 | >27 |
INH, isoniazid; RIF, rifampicin; STR, streptomycin; EMB, ethambutol; PZA, pyrazinamide; FQ, resistant to at least one fluoroquinolone.