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. 2014 May 5;155(7):2635–2646. doi: 10.1210/en.2014-1040

Figure 1.

Figure 1.

EPS altered expression of immune response genes in E12.5 placentas. Analyses of TaqMan Low Density Mouse Immune Array revealed significant main effects of EPS. Differentially expressed genes in males (A) and females (B) are organized into functional clusters, and their relative expression values are shown. The proapoptotic factor, FASL, was up-regulated in prenatally stressed males and females. In males, 11 additional genes were up-regulated by prenatal stress, including genes involved in cytokine signaling, chemokine signaling, cell surface antigens, and endothelial molecules. Significant interactions between EPS and NSAID treatment were detected for IL-6 and CCR7. Post hoc comparisons revealed increased IL-6 and CCR7 in stressed male placentas relative to nonstressed males. Maternal NSAID treatment rescued these EPS effects, as placental IL6 and CCR7 of EPS/NSAID males did not differ from controls. EPS decreased CCL2 in females (B). No main effects of NSAID were observed. Data are mean ± SEM. *, P < .05 main effect of EPS by two-way ANOVA; #, P < .05 vs CON/VEH by Tukey HSD. CON, control; EDN1, endothelin 1; PTPRC, protein tyrosine phosphatase receptor C; SELP, P-selectin; VEH, vehicle.