Figure 6.

Induced hypothalamic Sim1 homozygous mice in metabolic cages show normal diet-induced thermogenesis and normal consumption of chow diet but increased water intake. A, and B, Hourly rate of oxygen consumption and response to shift from chow to high fat diet (A) was measured in a cohort of 10-week-old male control or iKO mice treated with tamoxifen at age 8 weeks. B, Increase in overall mean hourly oxygen consumption in response to shift to high fat diet did not differ between control and iKO groups. C, In metabolic cages, iKO mice did not consume more chow but drank significantly more water than controls. *, P < .05; **, P < .01; ***, P < .001, n.s. indicates not significant.