Table 4.
Alternate multiple linear regression model performed in the discovery cohort and including both angiogenic factors independently associated with the late-NVC pattern and SSc-related disease characteristics associated univariately with P ≤ 0.10 with the late-NVC pattern
| NVC pattern | P value | Multiple linear regression (r) |
P value | ||
|---|---|---|---|---|---|
| Early/Active (n = 36) |
Late (n = 24) |
||||
| Modified Rodnan skin score > 14, n (%) | 6 (17) | 13 (54) | 0.005* | 0.50 | < 0.0001 |
| History of digital ulcers, n (%) | 13 (36) | 16 (67) | 0.03* | 0.25 | 0.04 |
| Positive antitopoisomerase antibodies, n (%) | 12 (33) | 16 (67) | 0.02* | ||
| FVC < 75, n (%) | 5 (14) | 8 (33) | 0.1* | ||
| DLCO/VA < 75%, n (%) | 9 (25) | 14 (58) | 0.02* | ||
| Treatment with angiotensin-converting enzyme inhibitors, n (%) | 8 (22) | 11 (46) | 0.09* | ||
| Treatment with endothelin-receptor antagonists and/or PDE5 inhibitors, n (%) | 4 (11) | 8 (33) | 0.08* | ||
| EPCs (106 Lin-mononuclear cells), median (range) | 64 (21-573) | 31 (5-300) | < 0.0001* | -0.45 | 0.005 |
| VEGF (pg/ml), median (range) | 470 (156-1,146) | 814 (189-1,564) | 0.01* | 0.37 | 0.01 |
DLCO/AV, diffusing capacity for carbon monoxide/alveolar volume; FVC, forced vital capacity; NVC, nailfold videocapillaroscopy. * Variables included in multiple regression analysis