Table 2.
Differences in PPARα biology between rodents and humans
| Feature | Rodent | Human |
|---|---|---|
| Peroxisome proliferation in response to PPARα agonists | + | − |
| Hepatomegaly in response to PPARα agonists | + | − |
| Plasma TG lowering by PPARα agonists | + | + |
| Effect PPARα agonist on liver transaminase | ↓ | ↑ |
| Highest expression of PPARα | Liver, heart, brown adipose tissue, heart | Liver, heart, brown adipose tissue?, small intestine |
| Robust common target genes | Cpt1a, Fgf21, Acox1 Hmgcs2, Angptl4 |
CPT1A. FGF21, ACOX1 HMGCS2, ANGPTL4 |
| Mouse-specific targets | Mgll, Bbox1, Decr1, Fbp2 | |
| Human-specific targets | PCK1, MBL2, APOA2 |