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. 2014 Feb 19;3(4):394–407. doi: 10.1016/j.molmet.2014.01.014

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

Assessment of energy balance parameters in NRic-KO mice. (A) Daily food intake is illustrated for individually housed, 12-week-old NRic-KO and control mice. (B) Daily energy expenditure was monitored using the Oxymax/CLAMS indirect calorimetry system in 12-week-old mice of the indicated genotypes. (C) Total activity in light and dark periods in mice of the indicated genotypes is depicted. (D) Respiratory exchange ratio (RER) (VCO₂/VO₂) during the light and dark periods is shown. (E) Core body temperature measured during the light phase in mice of the indicated genotypes. Values represent mean±SEM of 4–5 animals of each genotype. ∗∗∗ p<0.001, ∗∗ p<0.01, ∗ p<0.05.