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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2013 May 17;63:304–312. doi: 10.1016/j.freeradbiomed.2013.05.016

Table 3.

The Most Statistically Significant Associations for Single Genetic Variants with Rate of Change in FEV1 by Race/Ethnicity, for Participants in the Health ABC Studya

Population and
Gene		 SNP Chr Base Pair
Position		 Minor
Allele		 MAF β (ml/yr)b P Value Genetic
Modelc
African Americans
mGST3 rs10800120 1 163871934 A 0.20 −5.8 ± 2.0 0.004 Additive
SOD3 rs8192287 4 24405666 T 0.02 −19.8 ± 5.4 2.45 × 10−4 Additive
GSR rs8190996 8 30673548 T 0.32 12.3 ± 3.8 0.001 Recessive
European Americans
GSTA4 rs6904771 6 52964138 G 0.02 −13.2 ± 4.2 0.002 Additive

Abbreviations: FEV1, forced expiratory volume in 1 s; SNP, single nucleotide polymorphism; Chr, chromosome; MAF, minor allele frequency; β, regression coefficient; mGST3, microsomal glutathione S-transferase 3; SOD3, superoxide dismutase 3; GSR, glutathione reductase; GSTA4, glutathione S-transferase A4.

a

Data shown for associations with P < 0.005 for the SNP single-marker effect on rate of change in FEV1, sorted by race/ethnicity, chromosome and base pair position. Statistically significant associations satisfying the Bonferroni-adjusted threshold (African Americans: P < 2.3 × 10−4; European Americans: P < 3.0 × 10−4) are bolded.

b

Regression coefficient and standard error for the SNP × time product term in the corresponding mixed effects model.

c

Genetic model is defined in reference to the minor allele for each SNP.