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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2013 May 17;63:304–312. doi: 10.1016/j.freeradbiomed.2013.05.016

Table 4.

The Most Statistically Significant Associations for Single Genetic Variants with Rate of Change in FEV1/FVC by Race/Ethnicity, for Participants in the Health ABC Studya

Population and
Gene		 SNP Chr Base Pair
Position		 Minor
Allele		 MAF β (%/yr)b P Value Genetic
Modelc
African Americans
GLRX2 rs35358794 1 191336492 A 0.06 0.29 ± 0.09 0.001 Additive
SOD2 rs4342445 6 160018212 A 0.15 −0.53 ± 0.17 0.002 Recessive
TXN2 rs2267337 22 35200417 T 0.22 −0.16 ± 0.05 0.002 Additive
TXN2 rs2281082 22 35202696 T 0.22 −0.15 ± 0.05 0.004 Additive
PRDX4 rs528960 23 23601182 C 0.24 0.19 ± 0.06 0.003 Dominant
European Americans
GCLC rs17883901 6 53517996 T 0.09 −0.86 ± 0.21 4.50 × 10−5 Recessive
GSTO2 rs157077 10 106027884 C 0.46 −0.09 ± 0.03 3.68 × 10−4 Additive

Abbreviations: FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; SNP, single nucleotide polymorphism; Chr, chromosome; MAF, minor allele frequency; β, regression coefficient; GLRX2, glutaredoxin 2; SOD2, superoxide dismutase 2; TXN2, thioredoxin 2; PRDX4, peroxiredoxin 4; GCLC, glutamate-cysteine ligase (catalytic subunit); GSTO2, glutathione S-transferase O2.

a

Data shown for associations with P < 0.005 for the SNP single-marker effect on rate of change in FEV1/FVC, sorted by race/ethnicity, chromosome and base pair position. Statistically significant associations satisfying the Bonferroni-adjusted threshold (African Americans: P < 2.3 × 10−4; European Americans: P < 3.0 × 10−4) are bolded.

b

Regression coefficient and standard error for the SNP × time product term in the corresponding mixed effects model.

c

Genetic model is defined in reference to the minor allele for each SNP.