Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2013 May 17;63:304–312. doi: 10.1016/j.freeradbiomed.2013.05.016

Table 5.

The Most Statistically Significant Gene-by-Smoking Interactions with Rate of Change in FEV1 and FEV1/FVC by Race/Ethnicity, for Participants in the Health ABC Studya

Phenotype Population
and Gene		 SNP-Smoking
Interactionc 		Chr Base Pair
Position		 Minor
Allele		 MAF Interaction
Effectd 		P Value Genetic
Modele
FEV1 African Americans
GLRX2 rs34552619 × smoking status 1 191331738 C 0.08 −32.4 ± 8.8 2.74 × 10−4 Dominant
IDH1 rs1437410 × smoking pack-years 2 208825562 C 0.22 −1.2 ± 0.4 6.27 × 10−4 Recessive
European Americans
SOD3 rs1007991 × smoking status 4 24409783 C 0.34 17.9 ± 5.7 0.002 Additive
GSTZ1 rs2111699 × smoking pack-years 14 76858350 G 0.32 −0.4 ± 0.1 9.55 × 10−4 Recessive
FEV1/FVC African Americans
mGST3b rs7554034 × smoking status 1 163877088 A 0.46 0.56 ± 0.21 0.007 Recessive
IDH3Bb rs6115381 × smoking status 20 2590376 G 0.37 −0.82 ± 0.23 4.60 × 10−4 Recessive
SOD1 rs2070424 × smoking status 21 31961191 G 0.19 0.68 ± 0.19 3.62 × 10−4 Dominant
G6PD rs2472394 × smoking pack-years 23 153424545 A 0.13 −0.012 ± 0.003 7.75 × 10−4 Dominant
European Americans
mGST3 rs2297765 × smoking status 1 163888831 T 0.44 0.45 ± 0.12 1.13 × 10−4 Additive
SOD3b rs2284659 × smoking status 4 24403895 T 0.37 0.64 ± 0.22 0.004 Recessive
IDH3B rs6115381 × smoking pack-years 20 2590376 G 0.07 −0.008 ± 0.002 3.82 × 10−4 Additive
IDH3B rs6107100 × smoking pack-years 20 2592685 A 0.07 −0.008 ± 0.002 3.68 × 10−4 Additive
IDH3B rs2073192 × smoking pack-years 20 2592996 A 0.07 −0.008 ± 0.002 2.10 × 10−4 Additive

Abbreviations: FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; SNP, single nucleotide polymorphism; Chr, chromosome; MAF, minor allele frequency; GLRX2, glutaredoxin 2; IDH1, isocitrate dehydrogenase 1; SOD3, superoxide dismutase 3; GSTZ1, glutathione S-transferase Z1; mGST3, microsomal glutathione S-transferase 3; IDH3B, isocitrate dehydrogenase 3B; SOD1, superoxide dismutase 1; G6PD, glucose-6-phosphate dehydrogenase.

a

Data shown are for the most statistically significant gene-by-smoking interactions for each phenotype and race/ethnicity analysis. Statistically significant interactions satisfying the Bonferroni-adjusted threshold (African Americans: P < 2.3 × 10−4; European Americans: P < 3.0 × 10−4) are bolded.

b

These nominally significant (P < 0.01) interactions were selectively presented since they represent gene-level replications of most statistically significant interactions in another phenotype and race/ethnicity analysis.

c

Smoking status was defined as a two-level categorical variable: smokers vs. non-smokers (reference group) during follow-up; smoking pack-years was modeled as a continuous variable.

d

Beta coefficient and standard error for the SNP × smoking × time product term in the corresponding mixed effects model; ml per year for the effect on rate of change in FEV1 and % per year for the effect on rate of change in FEV1/FVC.

e

Genetic model is defined in reference to the minor allele for each SNP.