Table 4.
CTLA-4 genotypes and allele frequencies in relation to some clinical manifestations of Behçet's disease in Egyptian patients.
| CTLA-4 49 A | Genotypes frequency, n (%) | Alleles frequency, n (%) | |||
|---|---|---|---|---|---|
| AA | AG | GG | A | G | |
| Skin pathergy | |||||
| With | 23 (60.5)* | 13 (34.2) | 2 (5.3) | 59 (77.6)# | 17 (22.4) |
| Without | 8 (36.4) | 8 (36.4) | 6 (27.3) | 24 (54.5) | 20 (45.5) |
| Retinopathy | |||||
| With | 21 (60.0)† | 12 (34.3) | 2 (5.7) | 54 (77.1)¶ | 16 (22.9) |
| Without | 14 (40.0) | 9 (36.0) | 6 (24.0) | 29 (58.0) | 21 (42.0) |
| Vasculitis | |||||
| With | 22 (61.1)♯ | 12 (33.3) | 2 (5.6) | 56 (77.8)§ | 16 (22.2) |
| Without | 9 (37.5) | 9 (37.5) | 6 (25.0) | 27 (56.2) | 21 (43.8) |
*P value = 0.018; odds ratio = 8.63 in patients with versus without skin pathergy test.
# P value = 0.009; odds ratio = 2.89 in patients with versus without skin pathergy test.
† P value = 0.041; odds ratio = 6.31 in patients with versus without retinopathy.
¶ P value = 0.027; odds ratio = 2.44 in patients with versus without retinopathy.
♯ P value = 0.028; odds ratio = 7.33 in patients with versus without vasculitic manifestations.
§ P value = 0.014; odds ratio = 2.72 in patients with versus without vasculitic manifestations.