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. 2014 Jun 17;5:293. doi: 10.3389/fimmu.2014.00293

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Copyright © 2014 Li, Symonds, Miao, Sanderson and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of nanoAPC designed to deliver peptide-MHC complexes and IL-2 to their receptors on antigen-specific T lymphocytes. (A) Graphical representation of nanoAPC. (B) Electron microscopy shows purified nanoAPC from IL-2 engineered 721.221 B cells. (C) Confocal microscopy shows nanoAPC stained with anti-IL-2 (red) and anti-HLA A2 (green). (D) Confocal microscopy shows interaction of nanoAPC (green) with T lymphocytes after 1 and 6 h in vitro. After 6 h, nanoAPCs are internalized into T cells. (E) Distribution of nanoAPC (green) prepared from mouse dendritic cells in T lymphocyte areas of mouse lymph node 48 h after i.v. injection. B cells were stained by B220 (orange).