Figure 6.

Bach2 inhibits T-effector differentiation and stabilizes Tregs. Cytokines present in the environment regulate the phenotypic and functional fate of T cells. The combination of IL-2 and TGF-β creates an environment conducive for the generation of inducible Treg cells. (A) WT cells differentiated into FoxP3⁺ Treg cells when cultured with these cytokines, while Bach2 knockout cells converted into effector T cells. This suggests that Bach2 is (B) an instrumental regulator of the immune system through (C) inhibition of effector function and thereby, stabilization of Tregs.