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. 2014 Mar 12;3(4):408–418. doi: 10.1016/j.molmet.2014.02.001

Figure 3.

Figure 3

Impaired mitochondrial function has no effect on insulin action in FAO hepatocytes. (A) Basal respiration; (B) Mitochondrial function; (C) Extracellular acidification rate (ECAR); (D) ATP concentration; (E) Basal and insulin-suppressed (0.1 nM) glucose production; (F) Insulin action; and (G) Insulin signalling in vehicle and 0.5 nM oligomycin treated (24 h) FAO hepatocytes. (H) Basal respiration; (I) Mitochondrial function; (J) ECAR; (K) ATP concentration; (L) Basal and insulin-suppressed (0.1 nM) glucose production; (M) Insulin action; (N) Insulin signalling; and (O) Basal and insulin-suppressed (0.1 nM) glucose production in the presence of absence of wortmannin (100 nM) in vehicle and 1 nM rotenone treated FAO hepatocytes. Data presented as mean ± SEM, n = 3–6 biological replicates. Denotes significantly different from; † vehicle-treated cells, # vehicle/non-insulin-treated cells, * vehicle/insulin-treated cells, Δ designated difference (p < 0.05).