Table 1.
Characteristics of individuals without rheumatoid arthritis (RA) or osteoarthritis (OA) at baseline
| All participants without RA/OA | Later developed RA | Did not develop RA | P -value | Later developed OA | Did not develop OA | P -value | |
|---|---|---|---|---|---|---|---|
|
n |
33,567 |
786 |
32,781 |
|
3,586 |
29,981 |
|
|
Age
1
(years) |
46 (13) |
51 (13) |
46 (13) |
** |
52 (10) |
45 (13) |
** |
|
Sex (female) |
18,207 (54.2%) |
488 (62.1%) |
17719 (54.1%) |
** |
2,406 (67.1%) |
15,801(52.7%) |
** |
|
Smoking |
|
|
|
** |
|
|
** |
|
Current |
8,901 (26.5%) |
256 (32.6%) |
8,645 (26.4%) |
|
1,015 (28.3%) |
7,886 (26.3%) |
|
|
Former smoker |
7,908 (23.6%) |
212 (27.0%) |
7,696 (23.5%) |
|
945 (26.4%) |
6,963 (23.2%) |
|
|
Never smoker |
15,017 (44.7%) |
281 (35.6%) |
14,736 (45.0%) |
|
1,425 (39.7%) |
13,592 (45.3%) |
|
|
Hypertension |
12,186 (36.3%) |
339 (43.1%) |
11,847 (36.1%) |
** |
1,547 (43.1%) |
10,639 (35.5%) |
** |
|
Diabetes |
454 (1.4%) |
19 (2.4%) |
435 (1.3%) |
* |
61 (1.7%) |
393 (1.3%) |
|
|
Previous CV disease |
1,060 (3.2%) |
52 (6.6%) |
1,008 (3.1%) |
** |
158 (4.4%) |
902 (3.0%) |
** |
|
Angina |
673 (2.0%) |
35 (4.5%) |
638 (1.9%) |
** |
107 (3.0%) |
566 (1.9%) |
** |
|
MI |
441 (1.3%) |
16 (2.0%) |
425(1.3%) |
|
49 (1.4%) |
392 (1.3%) |
|
|
Stroke |
223 (0.7%) |
9 (1.1%) |
214 (0.7%) |
|
32 (0.9%) |
191 (0.6%) |
|
|
Family risk of CV disease |
15,692 (46.7%) |
414 (52.7%) |
15,278 (46.6%) |
** |
2,017 (56.2%) |
13,675 (45.6%) |
** |
|
Framingham risk score
2
|
9 (4 to 13) |
11 (7 to 16) |
8 (4 to 13) |
|
11 (7 to 15) |
8 (3 to 13) |
|
|
Weight
1
(kg) |
76 (14) |
77 (14) |
76 (14) |
|
77 (13) |
76 (14) |
|
|
BMI
2
(kg/m
2
) |
25.6 (23.5 to 28.1) |
26.3 (24.3 to 29.0) |
25.6 (23.4 to 28.1) |
** |
26.4 (24.2 to 29.0) |
25.4 (23.3 to 27.8) |
** |
|
Waist circumference
1
(cm) |
85 (11) |
86 (11) |
85 (11) |
* |
86 (11) |
85 (11) |
** |
|
Hip circumference
1
(cm) |
102 (8) |
103 (8) |
102 (8) |
** |
103 (8) |
101 (6) |
** |
|
Waist/hip ratio
1
|
0.84 (0.08) |
0.84 (0.08) |
0.84 (0.08) |
|
0.83 (0.07) |
0.84 (0.08) |
** |
|
Systolic blood pressure
2
(mmHg) |
131 (120 to 144) |
133 (122 to 146) |
131 (120 to 144) |
* |
133 (122 to 147) |
131 (120 to 143) |
** |
|
Diastolic blood pressure
1
(mmHg) |
79 (11) |
80 (11) |
79 (11) |
* |
81 (11) |
79 (11) |
** |
|
Serum cholesterol
1
(mmol/L) |
5.8 (1.2) |
6.0 (1.2) |
5.8 (1.2) |
** |
6.1 (1.2) |
5.8 (1.2) |
** |
|
HDL cholesterol
1
(mmol/L) |
1.40 (0.39) |
1.37 (0.39) |
1.40 (0.39) |
|
1.44 (0.40) |
1.39 (0.38) |
** |
| Serum triglycerides 2 (mmol/L) | 1.40 (0.98 to 2.07) | 1.51 (1.10 to 2.24) | 1.40 (0.97 to 2.06) | ** | 1.46 (1.02 to 2.12) | 1.37 (0.95 to 2.04) | ** |
1Values are mean (standard deviation) or numbers (%), or 2median (interquartile range). Non-respondents were excluded. BMI, body mass index; CVD, cardiovascular disease; HDL, high density lipoprotein; MI, myocardial infarction; OA, osteoarthritis; RA, rheumatoid arthritis. *P-value <0.05, **P-value <0.001, comparing individuals who developed RA and did not develop RA, or comparing individuals who developed OA and did not develop OA. All blood samples were non-fasting.