Table 2.
Effects of risk factors on incident RA and osteoarthritis, by multivariate logistic regression
| Odds ratio | 95% confidence interval | P -value | |
|---|---|---|---|
|
I - Main model – Rheumatoid arthritis (n = 739 patients and 30,829 controls)1 | |||
| Female gender |
1.50 |
1.29 to 1.75 |
<0.01 |
| Age2 |
1.03 |
1.02 to 1.04 |
<0.001 |
| Current smoker |
1.64 |
1.38 to 1.96 |
<0.001 |
| Former smoker |
1.32 |
1.10 to 1.59 |
<0.01 |
| Hypertension |
0.97 |
0.82 to 1.15 |
0.76 |
| Diabetes |
1.34 |
0.83 to 2.18 |
0.23 |
| Body mass index2 |
1.04 |
1.02 to 1.06 |
<0.001 |
| Previous CV disease |
1.52 |
1.11 to 2.07 |
<0.01 |
|
II - Alternative models (sensitivity analyses) - Rheumatoid arthritis | |||
|
A – After exclusion of patients with self-reported psoriasis (n = 573 patients and 30,829 controls)1 | |||
| Previous CV disease3 |
1.70 |
1.23 to 2.36 |
0.001 |
|
B – Including patients with hospital diagnosis of RA (n = 201 patients and 30,829 controls)1 | |||
| Previous CV disease3 |
1.90 |
1.10 to 3.27 |
0.02 |
|
C – Including patients with hospital diagnosis of RA after 1999 (n = 178 patients and 30,829 controls)1 | |||
| Previous CV disease3 |
|
2.26 |
1.26 to 3.99 |
|
D – Including patients with hospital diagnosis of RA after 2001 (n = 138 patients and 30,829 controls)1 | |||
| Previous CV disease3 |
2.51 |
1.33 to 4.73 |
<0.01 |
|
E – Including patients carrying the Shared Epitope (n = 313 patients and 30,829 controls)1 | |||
| Previous CV disease3 |
1.76 |
1.13 to 2.74 |
0.01 |
|
F – Including patients carrying the Shared Epitope and excluding patients with self-reported psoriasis (n = 257 patients and 30,829 controls)1 | |||
| Previous CV disease3 |
1.96 |
1.24 to 3.10 |
<0.01 |
|
III - Model for osteoarthritis (n = 3,364 patients and 24,631 controls)1 | |||
| Female gender |
2.36 |
2.15 to 2.56 |
<0.001 |
| Age2 |
1.05 |
1.05 to 1.06 |
<0.001 |
| Current smoker |
1.42 |
1.30 to 1.56 |
<0.001 |
| Former smoker |
1.23 |
1.12 to 1.35 |
<0.001 |
| Diabetes |
0.90 |
0.66 to 1.22 |
0.49 |
| Body mass index2 |
1.06 |
1.05 to 1.07 |
<0.001 |
| Previous CV disease | 1.04 | 0.86 to 1.27 | 0.66 |
1Cases with complete data.
2Continuous variable, Odds ratio per one unit change.
3Multivariate model including the same variables as the main model for RA. CV, cardiovascular; RA, rheumatoid arthritis.