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. 2014 Apr 25;16(2):R103. doi: 10.1186/ar4552

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Copyright © 2014 Jones et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

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Scatterplots show minimal or no relationship of serum CXCL13 to high-sensitivity C-reactive protein or disease activity score in 28 joints C-reactive protein in the seropositive groups of the Dartmouth RA Cohort and the Sherbrooke Early Undifferentiated PolyArthritis Cohort. (A) In the Dartmouth RA Cohort, correlation analysis of log-transformed C-X-C motif chemokine 13 (LogCXCL13) and high-sensitivity C-reactive protein (LogCRP) does not show a relationship (n = 123, P = 0.07). (B) In the Dartmouth RA Cohort, correlation analysis of CXCL13 has a modest relationship with Disease Activity Score in 28 joints CRP (DAS28-CRP) (n = 23, P = 0.01). (C) In the recent-onset rheumatoid arthritis (RA) patients from the Sherbrooke Early Undifferentiated PolyArthritis (EUPA) Cohort, no relationship is identified between LogCXCL13 and LogCRP (n = 173, P = 0.08). (D) In the recent-onset RA patients from the Sherbrooke EUPA Cohort, no relationship is identified between LogCXCL13 and DAS28-CRP (n = 170, P = 0.28). Diagonal lines represent lines of best fit.