Figure 3.

Expression of ${\text{Lenti - siI}}_2^{\text{PP2A}}$ improves cognitive functions in htau mice. Approximately 11-month-old htau mice received brain infusion of the ${\text{Lenti - siI}}_2^{\text{PP2A}}$ (Lenti-siI₂) or the scrambled ${\text{Lenti - ssiI}}_2^{\text{PP2A}}$ (Lenti-ssiI₂; 2 μl each, 2 × 10⁹ TU/ml) into the hippocampal CA3 region under a stereotaxic instrument. Four weeks later, the associative short-term memory (STM) (A) and long-term memory (LTM) (B) were detected by step-down avoidance test (n = 8–10 for each group). The data were expressed as mean ± SD. *p < 0.05; **p < 0.01 vs. Lenti-ssiI₂/htau (htau mice infused with Lenti-ssiI₂).