Table 2.
OR impact on preeclampsia and HELLP.
| Gene variant | Preeclampsia compared to | HELLP compared to | Number | OR (95% CI) | References |
|---|---|---|---|---|---|
| Factor V Leiden mutation | Healthy pregnancy | 71 | 4.45 (1.31–15.31) | [69] | |
| Factor Leiden mutation 169G-A SNP |
Healthy pregnancy | 1,798 | 1.81 (1.14–2.87) | [70] | |
| Factor V Leiden mutation | Healthy pregnancy | 32 | 2.29 (0.56–9.32) | [45] | |
| Factor II prothrombin mutation | Healthy pregnancy | 32 | 6.03 (0.65–47.54) | [45] | |
| Three mutations | Healthy pregnancy | 7,522 | 1.84 (1.14–2.87) | [71] | |
| MTHFR 677C-T SNP | Healthy pregnancy | 2,250 | 1.01 (0.79–1.29) | [1] | |
| VEGF C −460T SNP | Healthy pregnancy | 71 | Adjusted OR 3.95 (1.51–6.08) |
[72] | |
| VEGFG 405C SNP | Healthy pregnancy | 71 | Adjusted OR 3.67 (1.05–1.75) |
[72] | |
| BclI polymorphism of GR gene | Healthy pregnancy | 17 | Adjusted OR 2.89 (1.45–5.74) |
[49] | |
| BclI polymorphism of GR gene | Severe preeclampsia | 150 | 2.56 (1.45–5.74) | [49] | |
| Polymorphism of EPHX gene | Healthy pregnancy | 87 | 2.0 (1.2–3.7) | [49] | |
| Fas TNFRSF6 gene | Healthy pregnancy | 84 | 2.7 (1.2–5.9) | [51] | |
| TLR-4 gene | Healthy pregnancy | 177 | 4.1 (1.7–9.8) | [52] | |
| Combined TLR-4 and NOD2 variant and high levels of IL-6 | Healthy pregnancy | 177 | 6.9 (2.1–23.2) | [52] | |
| I/II genotype of LEPR gene | Healthy pregnancy | 40 | 3.8 (0.8–18.0) | [73] | |
| LEPR 223G allele | LEPR 23A/A genotype |
24 | 1.92 (1.07–3.41) | [54] |