Effects of D2 and α2-adrenergic receptor antagonists on (A) CA release and (B) clearance in the mPFC evoked by VTA stimulation. Left: [CA]max and T1/2 over time; baseline (BL) and saline (SAL) time points are averaged from 4 samples each, followed by individual time points after drug administration at time 0 (SAL, saline; IDA, idazoxan; RAC, raclopride). Right: Data from the left panels are collapsed across time into 20-min epochs; n=6/group. *comparisons significantly different, p<0.05.