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Phagocytosis of sRBCiC3b by CR3-expressing COS-7cells as measured with the Phagocytic Index. Phagocytic Index, mean number of internal sRBCiC3b/100 COS-7 cells. F941V significantly impairs phagocytosis (P = 0.002). No significant difference observed between WT and either common polymorphism M441T (P = 0.74) and A858V (P = 0.92), or the rare variant G1145S (P = 0.37).
