Table 5.
Comparing patients with or without interstitial lung disease
|
Patients with ILD |
Patients without ILD |
P value | |
|---|---|---|---|
| (n = 61) | (n = 95) | ||
| Male/female |
28/33 |
33/62 |
0.16 |
| Mean (median) age (years) |
69.3 ± 1.6 (71) |
67.3 ± 1.3 (71) |
0.26 |
| MPO-ANCA |
60 (98.3) |
70 (73.7) |
<0.001 |
| PR3-ANCA |
3 (4.9) |
15 (15.8) |
0.038 |
| Serum creatinine (mg/dl) |
1.61 ± 0.23 |
1.83 ± 0.19 |
0.45 |
| Disease severity |
0.059 |
||
| Localised |
1 (1.7) |
3 (3.1) |
|
| Early systemic |
21 (34.4) |
15 (15.8) |
|
| Generalised |
31 (50.8) |
60 (63.2) |
|
| Severe |
8 (13.1) |
17 (17.9) |
|
| General performancea | |||
| 0/1/2/3/4 |
11/25/11/12/2 |
11/33/17/28/6 |
0.47 |
| BVASb | |||
| BVAS |
15.4 ± 1.0 |
18.4 ± 0.8 |
0.019 |
| General |
49 (80.3) |
69 (72.6) |
0.27 |
| Cutaneous |
13 (21.3) |
26 (27.4) |
0.39 |
| Mucous membranes/eyes |
5 (8.2) |
15 (15.8) |
0.17 |
| Ear, nose, and throat |
9 (14.8) |
33 (34.7) |
0.006 |
| Chest |
22 (36.1) |
41 (43.2) |
0.38 |
| Cardiovascular |
1 (1.7) |
11 (11.6) |
0.012 |
| Abdominal |
0 (0) |
2 (2.1) |
0.25 |
| Renal |
44 (72.1) |
65 (68.4) |
0.62 |
| Nervous system | 28 (45.9) | 47 (49.5) | 0.66 |
Values expressed as mean ± standard error or number (percentage) unless otherwise noted. ANCA, antineutrophil cytoplasmic antibody; BVAS, Birmingham Vasculitis Activity Score; ILD, interstitial lung disease; MPO, myeloperoxidase; MPA, microscopic polyangiitis; PR3, proteinase-3. aGeneral performance was categorised according to the World Health Organization Performance Status except category 5 (death). bDisease activity and patterns of organ involvement were defined by the BVAS 2003 scoring system.