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. 2014 Mar 4;2014:409547. doi: 10.1155/2014/409547

Table 1.

Summary of the main location and function of facilitative glucose transporter family [7, 8, 156].

Protein Major sites of expression Proposed function/major substrate Major species studied
GLUT1 Many cell types (e.g., erythrocytes, brain); fetal tissues Basal glucose uptake; transport across blood-tissue barriers Rodents, humans, horses, cows, dogs, pigs
GLUT2 Kidney, small intestine, liver, pancreatic islets, brain High-capacity low-affinity facilitated glucose and fructose transporter Rodents, humans, horses, cows
GLUT3 Brain (neurons) and testis High-affinity facilitated glucose transporter; neuronal transport Rodents, humans, cows, dogs, pigs
GLUT4 Striated muscle, fat, heart High-affinity facilitated glucose transporter; insulin-regulated transport; linked to IR/diabetes Rodents, humans, horses, cows, dogs, pigs
GLUT5 Small intestine, kidney, striated muscle, fat, testis Facilitated fructose transporter Rodents, humans, horses, cows, dogs, pigs
GLUT6 Leukocytes, brain, spleen Facilitated glucose transporter
GLUT7 Small intestine, colon, testis Transport of glucose and fructose
GLUT8 Testis, brain, blastocyst, striated muscle, fat, liver, spleen, lung Facilitated glucose transporter widely expressed; neuronal transport; insulin-responsive transport in blastocyst Rodents, humans, cows, horses
GLUT9 Liver, kidney, small intestine Facilitated urate (glucose) transporter Rodents, humans
GLUT10 Striated muscle, lung, liver, pancreas
GLUT11 Striated muscle Muscle-specific; facilitated glucose/fructose transporter Rodents, humans
GLUT12 Striated muscle, fat, prostate, mammary gland A second insulin-responsive facilitated GLUT? Rodents, humans, cows, horses
HMIT Brain, fat H+/myo-inositol cotransporter
GLUT14 Testis Orphan transporter