Table 2.

Differences in immune responses in subjects with week 24 virological response (VR) versus no response (NR).

Antigen	Baseline immune responses			Change in immune response, week 24 – baselinec
	Week 24 NR median (5%, 95% range)	Week 24 VR median (5%, 95% range)	P valuea	Week 24 NR median, (5%, 95% range)	Week 24 VR median (5%, 95% range)	P value
INFγ-core	0 (0, 8)	0 (0, 3)	0.19	0 (−7, 3)	0 (−1, 7)	0.29
IFNγ-NS3	0 (0, 9)	0 (0, 23)	0.66	0 (−7, 5)	0 (−23, 5)	0.63
IFNγ-NS5	0 (0, 11)	0 (0, 13)	0.45	0 (−4, 3)	0 (−13, 1)	0.22
IFNγ-Sumb	1 (0, 20)	1 (0, 24)	0.77	0 (−13, 4)	0 (−24, 5)	0.75
IFNγ-Candida	35 (0, 415)	15 (0, 178)	0.60	−3 (−163, 103)	−9 (−119, 93)	0.43
IL10-core	0 (0, 7)	0 (0, 33)	0.30	0 (−7, 1)	0 (−4, 3)	0.84
IL10-NS3	0 (0, 23)	0 (0, 111)	0.03	0 (−27, 59)	−1 (−111,3)	0.01
IL10-NS5	0 (0, 17)	0 (0, 49)	0.28	0 (−17, 7)	0 (−49, 0)	0.06
IL10-Sumb	0 (0, 63)	1 (0, 116)	0.09	0 (−55, 69)	−3 (−116, 3)	0.05
IL10-Candida	1 (0, 243)	0 (0, 456)	0.95	0 (−243, 65)	0 (−273, 11)	0.84

^aP values calculated using the non-parametric Kruskal–Wallis test.

^bSum of responses [spot forming cells (SFC)] to hepatitis C virus (HCV) proteins core, NS3 and NS5.

^cNumbers of SFC at baseline subtracted from SFC at week 24 (negative number indicates decreased response).