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. 2014 May 27;111(23):8553–8558. doi: 10.1073/pnas.1408048111

Fig. 2.

Fig. 2.

Identification of a Be-specific adaptive immune response in the lung and spleen of HLA-DP2 transgenic (Tg) mice. Frequency of Be-specific T cells in lung (A) and spleen (B) of wild-type (WT) FVB/N (Left) and HLA-DP2 Tg (Right) mice using IFN-γ and IL-2 ELISPOT is shown. Data are expressed as the mean spot-forming units (SFUs) per 5 × 105 cells, and median values are indicated with solid lines. Data shown represent 15 mice per group from five separate experiments. (C) IFN-γ levels in supernatants of lung homogenates were analyzed by Luminex from WT FVB/N (empty bars) and HLA-DP2 transgenic (Tg) (filled bars) mice exposed to PBS or BeO for 3 wk. Data represent a total of 11 mice from three separate experiments.