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. 2014 May 27;111(23):8565–8570. doi: 10.1073/pnas.1405514111

Fig. 6.

Fig. 6.

Proposed model of IL-15 trans-presentation in five steps. IL-15 and IL-15Rα are preassociated within presenting cells prior from emerging to the cell surface. (i) IL-15 is trans-presented by IL-15Rα at the surface of presenting cells to IL-15 responding cells expressing CD122/CD132 dimeric receptor. (ii) Membrane-bound IL-15.IL-15Rα complexes are cleaved following trans-presentation. (iii) The IL-15 receptor undergoes conformational change. (iv) IL-15.IL-15Rα complexes are internalized inside responding cells (v) and recycled for residual proliferation of responding cells. Signaling during IL-15 trans-presentation (lightning symbol) decreases following IL-15Rα cleavage.