Table 1.
Suppression of KCC2-activity measured as shift in Eglycine by 0.5 mM furosemide across different nuclei and species.
Mouse | Gerbil | |||||
---|---|---|---|---|---|---|
LSO | MSO | SPN | LSO | MSO | SPN | |
Control Eglycine | −68.6 ± 8.7 mV | −75.8 ± 15.7 mV | −90.6 ± 8.6 mV | −62.9 ± 4.9 mV | −67.4 ± 12.4 mV | −58.1 ± 3.03 mV |
Furosemide Eglycine | −51.0 ± 8.2 mV | −52.2 ± 15.4 mV | −54.5 ± 14.3 mV | −47.0 ± 13.7 mV | −49.0 ± 12.8 mV | −36.4 ± 5.4 mV |
Δ Eglycine | 17.6 mV | 23.6 mV | 36.2 mV | 15.9 mV | 18.4 mV | 21.7 mV |
n | 6 | 6 | 7 | 6 | 6 | 4 |
Significance | p = 0.037 | p = 0.025 | p ≤ 0.001 | p = 0.035 | p = 0.018 | p = 0.014 |