Figure 2.

Representative images obtained from Faxitron X-ray imaging. Panel A shows 4 typical tumor bearing tibiae in control (0% Curcumin in diet) animals. Significant osteosclerotic pattern in the cancer cell injected area of the tibiae are shown. However, there was also extensive soft tissue invasion and participation. Panel B shows representative tibiae obtained from the animals treated with the 1% curcumin diet, either in the preventive mode (top 3 specimens) or in the therapy mode (bottom 3 specimens). The overall radiographic pattern differences between the two groups is very similar. There was a significant reduction in the osteosclerotic nature of the metastatic lesion as well as the soft tissue participation as the curcumin dosing increases. Panel C shows the radiographic pattern obtained from tibiae in the 2% curcumin diet treated animals, with the top three specimens from the preventive mode and the bottom three specimens showing the therapy mode. The results presented in the following figures and table represent the information obtained in the “therapy” mode. Note the marked reduction in the extent of tumor progression as well as the metastatic lesions in both modes showing a near-normal pattern with no evidence of osteosclerotic changes and soft tissue involvement.