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(A) Graph of the patient’s platelet levels just before and after bevacizumab-FOLFIRI administration was resumed. Testing of patient’s serum for drug-dependent platelet antibodies by flow cytometry assay showed strong IgG antibody reactivity (MFI = 577.3) in the patient’s acute serum only in the presence of irinotecan (B) (dark histogram), but not with normal control serum and drug (C) (dark histogram). MFI = median fluorescence intensity.
