Table 1.
Summary of some SV-LAAOs and the tumor cell lines in which they were tested
| Snake species | LAAO | Tumor cell lines | Methodology | References |
|---|---|---|---|---|
|
Agkistrodon acutus |
ACTX-6 |
A549 |
MTT |
[23] |
| |
ACTX-8 |
HeLa |
MTT, DNA fragmentation |
[57] |
| |
|
|
Activation of caspases 3 and 9 |
|
|
Agkistrodon contortrix laticinctus |
ACL LAO |
HL-60 |
DNA fragmentation |
[14] |
|
Agkistrodon halys |
|
L1210 |
DNA fragmentation |
[32] |
| |
|
MOLT-4 |
||
| |
|
HL-60 |
|
|
|
Agkistrodon halys pallas |
|
A549 |
DNA fragmentation |
[59] |
|
Bothrops atrox |
BatroxLAAO |
HL-60 |
MTT |
[13,27] |
| |
|
PC12 |
Annexin V |
|
| |
|
B16F10 |
Activation of caspases |
|
| |
|
Jurkat |
|
|
|
Bothrops moojeni |
BmooLAAO-I |
HL-60 and EAT |
MTT and DNA fragmentation |
[60] |
|
Bothrops pirajai |
BpirLAAO-I |
S180 |
MTT |
[20,26] |
| |
|
|
DNA fragmentation |
|
| |
|
|
HFS |
|
| |
|
|
Activation of caspases 3, 8 and 9 |
|
| |
|
SKBR3 |
|
|
| |
|
HL-60 |
||
| |
|
HL-60.Bcr-Abl |
||
| |
|
EAT |
|
|
|
Bungarus fasciatus |
BF-LAAO |
A549 |
|
[49] |
|
Calloselasma rhodostoma |
CR-LAAO |
Jurkat |
|
[34] |
|
Crotalus atrox |
Apoxin-I |
HL-60 |
DNA fragmentation |
[33,54] |
| |
|
A2780 |
|
|
| |
|
HUVEC |
|
|
| |
|
KN-3 |
|
|
|
Eristocophis macmahoni |
LNV-LAO |
MM6 |
DNA fragmentation |
[53] |
|
Ophiophagus hannah |
|
SNU-1 |
MTT |
[25,61] |
| |
|
B16F10 |
DNA fragmentation |
|
| |
|
MCF-7 |
Activation of caspases |
|
| |
|
A549 |
|
|
| Vipera berus berus | HeLa and K562 | DNA fragmentation | [55] |