Table 1. Previous DTI studies on ZNF804A rs1344706 genotype and white matter microstructure.
First Author | Year | MRI | N | Age | Method | Result |
---|---|---|---|---|---|---|
Voineskos (Voineskos et al., 2011) | 2011 | 1.5T | 62 HC | 37.4±12.7 | Tractography | Negative |
Kuswanto (Kuswanto et al., 2012) | 2011 | 3T | 64 HC89 SZ | 31.9±10.1 34.3±9.2 | ROI | Positive |
Sprooten (Sprooten et al., 2012) | 2012 | 1.5T | 50 HC83 HC84 sib-BP84 sib-BP | 22.7±1.7 21.1±2.4 21.4±2.8 | TBSS | Negative |
Wei (Wei et al., 2013) | 2013 | 1.5T | 69 HC100 SZ | 25.4±5.7 26.5±6.9 | TBSS | Negative |
Kuswanto et al. (Kuswanto et al., 2012): Patients with AA genotype (homozygous for risk allele) showed lower FA in parietal lobes than patients with AC or CC genotype. HC with AA genotype showed higher FA in the right temporal lobe than HC with AC or CC genotype.
DTI = diffusion tensor imaging; FA = fractional anisotropy; HC = healthy controls; SZ = schizophrenia; Sib = sibling; BP = bipolar disorder; ROI = region of interest; TBSS = tract-based spatial statistics.