Table 1. Inhibitory Activity against Human HDACs.

			IC50 (μM)d
compd	R1	R2	HDAC1	HDAC3	HDAC6
1aa		n-C7H15CO	0.0137	0.2450	11.50
1bb		H	0.0012	0.0034	0.049
2aa		n-C7H15CO	2.0	16.8	14.7
2bb		H	0.077	0.085	>30
3a	H	n-C7H15CO	1.90 ± 0.25	2.83 ± 0.34	NAc
3b	H	H	0.09 ± 0.02	0.06 ± 0.01	3.71 ± 0.27
3c	Me	n-C7H15CO	2.60 ± 0.45	3.56 ± 0.44	NA
3d	Me	H	0.12 ± 0.02	0.11 ± 0.02	4.32 ± 0.33
4a	H	n-C7H15CO	NAc	NAc	NAc
4b	H	H	16.82 ± 1.0	NAc	NAc
4c	Me	n-C7H15CO	NAc	NAc	NAc
4d	Me	H	13.86 ± 2.2	NAc	NAc

^aData reported in our previous work.³³

^bData reported by Williams et al.³¹

^cNo inhibitory activity observed at 20 μg/mL.

^dValues are expressed as the mean ± SD, and the test was performed in triplicate.