Scheme 2. Synthesis of Compounds 3g, 10a, and 10c–n.
Reagents and conditions: (a) 9b, EDCI, DMF; (b) 2,4-dichloropyrimidine, K2CO3, DMF, 80 °C; (c) R’NH2, Xantphos, Pd2(dba)3, Cs2CO3, 1,4-dioxane, 80 °C; (d) RNH2, Et3N, THF, 80 °C.
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