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. 2014 Jun 17;9(6):e99440. doi: 10.1371/journal.pone.0099440

Figure 8. Modulation of RXRα, COUP-TFII and ERβ transcriptional activities by ccrp1, ccrp2 and ccrp3.

Figure 8

A, B. HeLa cells transiently transfected with RXRα LBD (panel A) or COUP-TFII LBD (panel B) and the luciferase reporter gene were treated with either DMSO (0.1%, solvent control) or compounds of interest at 10 µM in absence or presence of 9-cis retinoic acid (RA) at different concentrations (100 nM for RXRα and 5 µM for COUP-TFII). C. HeLa cells transiently transfected with ERβ LBD and the luciferase reporter gene were treated with either DMSO (0.1%, solvent control) or ccrp1; ccrp2 and ccrp3 at 10 µM in absence or presence of E2 at 100 nM. For all panels, following 24 h treatments, luciferase activities were recorded and normalized. For each concentration point, data are shown relative to control (0.1% DMSO), as average of three independent measurements, with experimental errors shown as black lines.